Zonulin is a physiological modulator of intercellular tight junctions, which upregulation is involved in several diseases like celiac disease (CeD). The polyQ gliadin fragment binds to the CXCR3 chemokine receptor that activates zonulin upregulation, leading to increased intestinal permeability in humans. Here, we report a general hypothesis based on the structural connection between the polyQ sequence of the immunogenic CeD protein, gliadin, and enteric coccidian parasites proteins. Firstly, a novel interaction pathway between the parasites and the host is described based (...) on the structural similarities between polyQ gliadin fragments and the parasite proteins. Secondly, a potential connection between coccidial infections as a novel environmental trigger of CeD is hypothesized. Therefore, this report represents a promising breakthrough for coccidian research and points out the potential role of coccidian parasites as a novel trigger of CeD that might define a preventive strategy for gluten‐related disorders in general. Also see the video abstract here: https://youtu.be/oMaQasStcFI. (shrink)

It is often suggested that during development the brain barriers are immature. This argument stems from teleological interpretations and experimental observations of the high protein concentrations in fetal cerebrospinal fluid (CSF) and decreases in apparent permeability of passive markers during development. We argue that the developmental blood–CSF barrier restricts the passage of lipid‐insoluble molecules by the same mechanism as in the adult (tight junctions) rendering the paracellular pathway an unlikely route of entry. Instead, we suggest that both protein and passive (...) markers are transferred across the epithelium through a transcellular route. We propose that changes in volume of distribution can largely explain the decrease in apparent permeability for passive markers and that developmentally regulated cellular transfer explains changes in CSF protein concentrations. The blood–CSF tight junctions are functionally mature from very early in development, and it appears that transfer from blood into embryonic brain occurs predominately via CSF rather than the vasculature. BioEssays 30:237–248, 2008. © 2008 Wiley Periodicals, Inc. (shrink)

Evidence from numerous studies using the visual world paradigm has revealed both that spoken language can rapidly guide attention in a related visual scene and that scene information can immediately influence comprehension processes. These findings motivated the coordinated interplay account (Knoeferle & Crocker, 2006) of situated comprehension, which claims that utterance‐mediated attention crucially underlies this closely coordinated interaction of language and scene processing. We present a recurrent sigma‐pi neural network that models the rapid use of scene information, exploiting an utterance‐mediated (...) attentional mechanism that directly instantiates the CIA. The model is shown to achieve high levels of performance (both with and without scene contexts), while also exhibiting hallmark behaviors of situated comprehension, such as incremental processing, anticipation of appropriate role fillers, as well as the immediate use, and priority, of depicted event information through the coordinated use of utterance‐mediated attention to the scene. (shrink)

When a word is used metaphorically (for example “walrus” in the sentence “The president is a walrus”), some features of that word's meaning (“very fat,” “slow-moving”) are carried across to the metaphoric interpretation while other features (“has large tusks,” “lives near the north pole”) are not. What happens to these features that relate only to the literal meaning during processing of novel metaphors? In four experiments, the present study examined the role of the feature of physical containment during processing of (...) verbs of physical containment. That feature is used metaphorically to signify difficulty, such as “fenced in” in the sentence “the journalist's opinion was fenced in after the change in regime.” Results of a lexical decision task showed that video clips displaying a ball being trapped by a box facilitated comprehension of verbs of physical containment when the words were presented in isolation. However, when the verbs were embedded in sentences that rendered their interpretation metaphorical in a novel way, no such facilitation was found, as evidenced by two eye-tracking reading studies. We interpret this as suggesting that features that are critical for understanding the encoded meaning of verbs but are not part of the novel metaphoric interpretation are ignored during the construction of metaphorical meaning. Results and limitations of the paradigm are discussed in relation to previous findings in the literature both on metaphor comprehension and on the interaction between language comprehension and the visual world. (shrink)

Resumen Este artículo ofrece una lectura de la pintura renacentista según los principios establecidos por Leon Battista Alberti, uno de los primeros teóricos de la perspectiva en cuyo Tratado de pintura se refiere al cuadro como “una ventana abierta a la historia”. El concepto de historia empleado por Alberti, que se presta a numerosas interpretaciones, es abordado a partir de las reflexiones de Erwin Panofsky en torno a la perspectiva como “forma simbólica”, avanzando hacia una hipótesis en torno al carácter (...) simbólico de la configuración y representación del tiempo en el cuadro-ventana albertiano.This paper offers a reading of the renaissance painting according to the principles established by Leon Battista Alberti, one of the first theorists of perspective in painting which Trattato della pittura define the frame of the painting as “an open window into history”. The concept of history employed by Alberti, which lends itself to many interpretations, is approached from the reflections of Erwin Panofsky about the prospect as “symbolic form”, moving towards a hypothesis about the symbolic nature of the configuration and representation of time in the alberti’s window. (shrink)

The changes and general alarm of the current COVID-19 pandemic have amplified the sense of precariousness and vulnerability for family members who, in addition to the emotional trauma of the cancer diagnosis, add the distress and fear of the risks associated with infection. The primary objectives of the present study were to investigate the psychological impact of the COVID-19 pandemic on the parents of pediatric cancer patients, and the level of stress, anxiety, and the child’s quality of life perceived by (...) the parents during the COVID-19 epidemic. The parents of 45 consecutive children with solid and hematological tumors were enrolled. Four questionnaires were administered to the parents at the beginning of the pandemic lockdown. A 75% of parents exhibited remarkable levels of anxiety, with 60 subjects in state scale and 45 subjects in trait scale having scores that reached and exceeded the STAI-Y cut off. The bivariate matrix of correlation found a significant positive correlation between the IES-R and PSS scores. There was a positive correlation between the PSS and PedsQL scale and a negative correlation between IES-R and STAI-Y. The results confirm that parents of pediatric cancer patients have a high psychological risk for post-traumatic symptoms, high stress levels, and the presence of clinically significant levels of anxiety. (shrink)

Розкрито сутність поняття «рейтинг». Доведено значущість рейтингової оцінки для суб’єктів фінансового ринку, зокрема для страхових компаній, потенційних страхувальників, інвесторів та кредиторів.

Pia Becker entwirft eine Konzeption von Patientenautonomie, die sich im Gegensatz zu in der Medizinethik bisher dominierenden Konzeptionen an der grundsätzlichen Fähigkeit des Patienten zur Autonomie orientiert. Ausgangspunkt bildet die Notwendigkeit der informierten Einwilligung, die neben der Patientenautonomie vor allem auch die körperliche Integrität des Patienten schützt. Als Adäquatheitsbedingungen dienen die beiden normativen Funktionen der Patientenautonomie als Barriere und Schlüssel einer medizinischen Behandlung. Diese Konzeption von Patientenautonomie hat den Vorteil, Patienten besser vor Überforderungen zu bewahren und deren Bedarf an Unterstützungsangeboten (...) zur Förderung der Patientenautonomie deutlicher hervorzuheben. (shrink)

Altersarmut, Bildungsunterschiede, eine wachsende Kluft zwischen Arm und Reich - die deutsche Gesellschaft spaltet sich, und viele fordern mehr Soziale Gerechtigkeit. Die Autorin untersucht, wie sich das Verstandnis von Sozialer Gerechtigkeit in Philosophie und Politik gewandelt hat, und hinterfragt, inwieweit Politiker Soziale Gerechtigkeit als Akzeptanzmittel fur ihre Entscheidungen nutzen.

This paper sets out to conduct an embodied and situated aural analysis of what silence in Northern Norway is about, with the aim of bringing forward the background noise. The paper brings together theories on construction of the rural, time-space relations, soundscape ecology, and on affect and power, and it merges academic traditions about how to communicate findings from non-visual biased studies. This interdisciplinary framework provides a novel structure for both analysing material and communicating findings from embodied studies of listening (...) out. The study found that silence in Northern Norway is about not listening to the economy of scale, to the commodification of the natural conditions and the suppression of lifestyles and territory. The paper illustrates how power is an inherent part of listening and how listening is a practice that is enacted to create emotions that are associated with a specific time-space relation. (shrink)

The basics -- The dignity of the human person -- Autonomy, consent, refusing treatment and boundaries -- Ethics and non-autonomous patients -- Confidentiality, privacy, data protection, truth telling and trust -- Ethical issues at the beginning of life -- Ethical issues about babies, children and young adults -- Ethical issues at the end of life -- Dying and death: ethical issues -- Loss, grief and bereavement, burn-out and the wounded healer -- Conscientious objection and loyalties.

Traditional interpretations of Aristotle’s theory of perception mainly focus on uncovering the underlying mechanisms that are at stake when perceivers are affected by sensible qualities. Investigating the nature of sense perception is one of Aristotle’s main worries and one that he explicitly relates to the question of its causes (e. g.Sens. 436a16–17, 436b9) and its ends (e. g.de An. 434a30 ff.). Therefore I suggest that, in order to fully explain Aristotle’s view of perceptual phenomena, the possibilities, the constraints, and the (...) goals defined by the embodied and situated engagement of perceivers with the external world must be taken into account. Accordingly, in this paper, I provide an affective reading of Aristotle’s theory of perception. I shall ask what, in addition to functioning sense organs and appropriate response mechanisms, the perceiver contributes to perceptual content. Specifically, I propose to shed light on the significance of perceptual experience for the perceiver and I aim to show that, according to Aristotle, one’s biological and personal qualities are perceptually relevant, meaning that they underpin perception, rather than coming into play after perception has occurred and its objects have been discerned. The paper is divided into two parts, respectively dealing with sensory affections and more complex affective phenomena. As regards the domain of primal sense perception, I will focus on smell as a representative example: since Aristotle identifies it as the least developed of human sensory faculties, it will serve as a revealing illustration of how sense perception is informed and qualified by what, drawing on contemporary philosophical terminology, I will call ‘perceptual interests’, viz. the affective sense of what is at stake in the living being’s interaction with the environment. I will then proceed to consider the way more complex affective phenomena underpin perception by examining the case of emotions and that of virtues of character. By showing how perception is affectively inflected and how emotion is rooted in perception’s bodily nature, I aim to sketch out the general lines along which I believe that the Aristotelian theory of perception should be approached. (shrink)

Die Arbeit zur regionalen Variation der Intonation bietet einen Forschungsüberblick über existierende Studien zum Thema und widmet sich dann der Analyse der Intonation der kölnischen Regionalvarietät auf der Basis von spontansprachlichen Daten. Die Analyse kombiniert Methoden des autosegmental-metrischen Ansatzes mit denen der Interaktionalen Linguistik. Da sich der autosegmental-metrische Ansatz in den letzten Jahren zum gängigen Beschreibungsansatz in der Intonationsforschung entwickelt hat, ist auf diese Weise eine Vergleichbarkeit der verschiedenen Untersuchungsergebnisse gewährleistet. Der Ansatz der Interaktionalen Linguistik erlaubt es darüber hinaus, die (...) tatsächliche Verwendungsweise der Intonationsverläufe durch die Interaktionsteilnehmer aufzuzeigen. Im Zentrum des Interesses stehen zwei steigend-fallende Konturen, die typisch für das Kölnische sind. Sie werden auf phonetischer, tonologischer und phonologischer (d.h. konversationell-funktionaler) Ebene analysiert. Die Arbeit verdeutlicht die große Bandbreite formaler Variation und zeigt, wie die Beteiligten Intonation als Ressource zur Gestaltung der Interaktion nutzen. (shrink)

Developing virtues requires attending to the affective and cognitive components of virtue. The former component implies cultivating apt emotional responses to specific situations. The cognitive part requires the (meta) virtue of phronesis. In dealing with “Phronesis in educating emotions,” this article attends to the nature of emotions and phronesis as its role in cultivating good action habits and virtuous emotional habits. It understands emotion regulation as one of the functions of phronesis. In the broader sense, phronesis includes elements other than (...) deliberation, such as dialectics and rhetoric, which can be helpful to induce a certain suspicion or to persuade somewhat since our affectivity is susceptible to persuasion (i.e. Aristotle’s political dominion of emotions). As a topic in the intersection of moral psychology and moral philosophy, we get valuable insights into a psychologist’s work, Magda Arnold’s (1903–2002) emotion theory. Her understanding of emotion elicitation elucidates the relation between phronesis and emotions. The article focuses on one of the central elements of emotion elicitation, the appraisal. This piece can make the education of emotions for virtue development more understandable. At first glance, our initial appraisal may be hasty and inaccurate, leading to emotional reactions. However, with careful reflection, we can correct and improve upon our initial appraisal and subsequent emotions. If our initial assessment was flawed, this second, more thoughtful evaluation can be enhanced through phronesis. Due to the appraisal’s spontaneity, cultivating educated emotions requires values’ teaching, learning, and thus, appraising good things. With the development of virtues, intuitive estimates become adequate, so emotional responses are more attuned to diverse situations. (shrink)

Within the caring science paradigm, variations of a method of interpretation inspired by the French philosopher Paul Ricoeur's theory of interpretation are used. This method consists of several levels of interpretation: a naïve reading, a structural analysis, and a critical analysis and discussion. Within this paradigm, the aim of this article is to present and discuss a means of creating distance in the interpretation and the text structure by using narration in a poetic language linked to the meaning of the (...) text. Ricoeur's ‘Hermeneutical function of distanciation’ will be introduced, and this concept of distanciation will be illustrated with reference to narrations from a study of patient's life experiences living with chronic illness and home mechanical ventilation in Denmark. Distanciation in the interpretation objectifies the text, and narration in a poetic language creates a particular kind of mediation in the interpretation. That narration represents an interpreted understanding of the whole, which facilitates an appropriate and evocative presentation of the interpreted data. This way of objectifying the text through narration can contribute yet another perspective to Ricoeur's rich and varied theory of interpretation. (shrink)

Democracy is increasingly being challenged, by disengagement and by anti-pluralist movements (Levitsky and Ziblatt in How Democracies Die: What History Reveals About Our Future, Viking, New York, 2018; Wikforss in _Därför demokrati. Om kunskapen och folkstyret_ [Because of this, democracy. On knowledge and people’s rule] Fri Tanke, 2021; Svolik et al. in J Democr 34(1):5–20, 2023). This article draws upon a theoretical discussion about democracy, pluralism, and threats to democracy. Departing from Dewey, Laclau, Mouffe, Young and Allen, we address democracy (...) as an ideology that centers around pluralism, or an ever-increasing inclusion of voices from the margins as its goal. We argue that perceiving democracy pedagogically as a pluralistic ideology would support students’ democratic citizenship and equip them for a world where threats to democracy are being reported. Employing a case study on Finnish social studies textbooks, we analyze how democracy as well as threats to democracy are discursively portrayed. Our study shows that the textbooks present democracy as predominantly institutional and static. We also find that while disengagement is portrayed as a problem for democracy, anti-pluralist movements are generally not referred to as a threat. Additionally, we examine a discourse in the textbooks that connects freedom of speech with democracy in a way that favors a multitude of opinions, even antidemocratic ones, over creating space for marginalized voices. Drawing on the theoretical discussion and the results of the analysis, we argue that a focus on pluralism as the core of democracy makes the opposition between restricting hate speech and advocating for democracy redundant. (shrink)

En el ensayo se propone una reflexión crítica sobre los presupuestos lógicos de la categoría de igualdad y sus ambivalencias. A una premisa teórica, que enmarca los términos de lo que se configura como un problema conceptual, seguirá una breve reconstrucción histórico-filosófica, que tiene el objetivo de arrojar luz sobre cómo podemos, leyendo a un clásico, repensar críticamente las premisas teóricas de la igualdad normativa a través de una recuperación de la valorización aristotélica de la dimensión cognitiva y moral de (...) emociones como la cólera y la indignación. (shrink)

The boundary work approach has been established as one of the main ways to study controversies in science. However, it has been proposed that it does not meet the power dynamics of the scientific field sufficiently. This article concentrates on the intertwining of boundary work and power. It combines the boundary work approach developed by Thomas Gieryn and the analysis of power in the work of Pierre Bourdieu. Based on a literature review and an analysis of a controversy over therapeutic (...) touch, it finds four forms of boundary work: intradisciplinary, interdisciplinary, between science and society, and between science and other knowledge systems. The article shows how the different forms of boundary work reveal multiple power struggles, hierarchisations and tensions. The controversy appeared in Finnish nursing science when the Finnish Association of Sceptics gave its annual Humbug Award to a book on therapeutic touch. The book was based on a master’s thesis at the University of Tampere department of nursing science. The nursing scholars in the department reacted abruptly and banned certain books, which astonished the students, and a lively public debate followed. In the debate, nursing science was both defended and challenged. The framework of the study shows that the boundary work approach can be used to study different aspects of power. The article proposes that the framework could be used in other controversies as well to study the layers of power in boundary work. (shrink)

This article contributes to the current discussion on interdisciplinarity in the health research field. It focuses on the relationship between nursing research and gender research. Nursing research is a ‘health sciences’ field which draws from the social sciences, the humanities, and biomedicine. Previous research shows the difficulties that social scientists face in their efforts to integrate with biomedical scientists. The aim of this article is to analyse nursing researchers’ views about one potential collaboration partner in the social sciences and humanities: (...) gender research. The study draws its theoretical insights from research within the sociology of science. It uses ideas about the intertwining of power and knowledge, which is especially emphasised in the works of Pierre Bourdieu. The research material consists of 180 abstracts of nursing research articles that argue in some way about the relationship between nursing research and gender research. The Scopus database was selected because it covers nursing research in a broad sense. The scope of the study is long. The close reading of abstracts is inspired by rhetorical discourse analysis. We found three clearly different but also overlapping discourses that justified gender perspectives in nursing research: Gender research helps to highlight the socio-political context in nursing research; Gender research develops or reforms the nursing research tradition; and Gender research exists as a form of critique within nursing research. Most of the nursing research abstracts regard gender research positively for both external and internal reasons. The abstracts also demonstrate the tensions in the relationship and discuss the views and reasons that generate scepticism towards gender research in nursing research. (shrink)

In responding to Mathias Beck's thought-provoking article, it seems helpful to begin with an outline and comments on Beck's case as I understand it. For me, this overview throws up three problematic areas that I explore further under the headings of 1. examining the New Testament evidence, 2. sin as disobedience, and 3. obedience, grace, and freedom. Clearly, the author's thoughts in all their nuances are not always adequately accessible in translation. Nevertheless, I hope that I have grasped the main (...) thread of his argument. If I am right in my interpretation then Beck still has work to do to clarify and make explicit what is not only barely implicit but what is obscured by his central theme: that obedience to God's will is the mainstay of our relationship to God. (shrink)

Emotion Review, Volume 13, Issue 4, Page 277-281, October 2021.

The place of emotions in aesthetic response has long been a topic in contemporary philosophical theorizing. One aspect of the debate in particular seems to have become a recalcitrant problem: when experiencing fiction, we experience emotional reactions towards what we know not to exist. Is this rational? In fact, is it even possible? This article deals with the so‐called “paradox of fiction” from the viewpoint of ancient poetics. In the first section, I survey some of the main arguments proposed to (...) (dis)solve the paradox in analytic philosophy. In the second and the third sections, I address what I consider two problematic assumptions of existing analytic approaches: their prescriptive, “essentialist” attitude and their exclusive focus on matters of content. By offering a brief sketch of the ancient principles of “likelihood” and “vividness”, I argue that they provide a direct and cognitively realistic answer to the paradox insofar as they account for the neutralization of doxastic features in imaginative acts and ground affective responses to fiction in the phenomenon of “aesthetic immersion”, explained in experiential, rather than representational, terms. (shrink)

The Nordic countries have often been regarded as ideal states with respect to their organization of society, including, among other things, their democracy, public education systems, gender equality, and strong concern for nature. From the late twentieth century onward, an increasing interest in Nordic literature, film, and design—genres where social and environmental themes have been strongly highlighted—can be noted internationally.This discourse of the Nordic societies can be considered to contain both utopian and dystopian aspects. As Kjerstin Aukrust and Cecilie Weiss-Andersen (...) show in their article on French democracy, the Nordic, understood as a utopian motif, has been a long-standing topic in modern French... (shrink)

Im Zentrum des Bandes steht die Frage nach dem Zusammenhang von Erkenntnis- und Wissenschaftstheorie im Kontext der mittelalterlichen Rezeption der Texte des Aristoteles an Hof und Universitäten, und dabei insbesondere der für die Epistemologie einschlägigen Passagen in De anima und in den Zweiten Analytiken sowie ihre spätantike und arabische Vermittlung. In diesem komplexen Rezeptions- und vor allem Transformationsprozeß werden zugleich die wissenschaftlichen und gesellschaftlich-institutionellen Grundlagen für den okzidentalen Prozeß der Rationalisierung und der Aufklärung gelegt, deren "Dialektik" nicht nur die Geschichte (...) Europas bis zum heutigen Tag bestimmt. Die Beiträge des Bandes vermitteln damit nicht nur einen umfassenden und bisher in der Forschung in dieser Form nicht geleisteten Überblick über Reichweite und Grenzen der epistemologischen Debatten im 12. und 13. Jahrhundert sowie ihren jeweiligen historischen Ort in der Wissenskultur des Mittelalters, sondern stellen darüber hinaus in ihrer Gesamtheit auch einen Beitrag dar zu Fragen der Epistemologie der Gegenwart, etwa zum Problem der Axiomatik der Wissenschaften. Die Publikation schließt damit nicht nur ein Desiderat in der Erforschung der mittelalterlichen Philosophie, sondern bildet zugleich einen genuinen Beitrag zu gegenwärtigen Fragestellungen der Epistemologie. (shrink)

A recent report in the UK, Being Disabled in Britain: A Journey Less Equal, highlights the many inequalities, threats to dignity and discriminatory attitudes faced by disabled people. No doubt these are replicated in other countries. Using the evidenced-based findings from this report and the report’s invitation for those concerned to join the conversation on disability, this paper explores both the way in which the experiences of people with disabilities can sharpen up an understanding of Catholic social teaching and the (...) way in which that teaching contributes to a deeper theology of disability. Moreover, insights from this teaching demonstrate that people with disabilities contribute significantly and positively to society and to interpersonal relationships. (shrink)

This book offers a critical introduction to the work of American philosopher D. G. Leahy (1937-2014). Leahy's fundamental thinking can be characterized as an absolute creativity in which all creating is 'live' -- a happening occurring now that manifests a supersaturated polyontological actuality that is essentially created by the logic that characterizes it. Leahy leaves behind the categorial presuppositions of modern thought, eclipsing both Cartesian and Hegelian subjectivities and introducing instead an essentially new form of thinking founded in a nondual (...) logic of creation. The new thinking delineates the absolute unicity of existence as a creative interactivity beyond all traditional dichotomies (such as one vs. many, unity vs. plurality, identity vs. change): a fully "digitized" actuality that is nothing but newness, which inherently implies nothing but change. Through this new form of thinking, change itself is revealed to be the very essence of reality and mind. Any reader looking for a quantum leap beyond the thrall of modern and postmodern fixations is invited to hear and apprehend this new thinking that refuses to be conditioned by paradigms, categories, species, genera, walls, bridges, boundaries, or abstractions: an essentially free thinking that embodies creative novelty itself. (shrink)